Medicube Serums

Medicube’s serum range is the largest and most varied part of the brand, built around specific actives rather than one general formula. From regenerative PDRN and collagen to brightening vitamin C and gentle exfoliating acids, there’s a serum for nearly every concern. Here’s the full range, what each one does, and how to work out which one belongs in your routine.

What Are Medicube Serums?

Medicube’s serums sit at the heart of the brand’s routine, usually applied straight after toning and before a moisturiser locks everything in. Unlike a toner or a pad, a serum carries the highest concentration of active ingredients in the routine, so this is where most of the real skincare work happens.

The range spans several formats too. Some are lightweight drop serums, others come as single use ampoules, twist and click dispensers, or even a bubble texture that melts on contact with skin. Whatever the format, each one is built around a specific concern, whether that’s firmness, brightness, hydration, or pore refinement, so it’s worth picking based on what your skin actually needs rather than the prettiest bottle.

Key Ingredients in Medicube Serums

Across the range, four main families of ingredients come up again and again.

  • PDRN and Salmon DNA. A regenerative ingredient derived from salmon, used to support skin renewal, elasticity, and a plumper, more resilient look. It’s the backbone of the Pink line, including the flagship Peptide Serum.
  • Used in several forms, including hydrolysed collagen, atelocollagen, and soluble collagen, to support firmness and a bouncier feel across the Triple Collagen and Collagen Glow Booster ranges.
  • Brightening actives. Vitamin C, kojic acid, turmeric, and niacinamide turn up across the Deep Vita C and Kojic Acid Turmeric serums, aimed at dullness and uneven tone.
  • Exfoliating acids and retinol. AHA, BHA, PHA, and retinol appear in the Zero Pore and Retinol NMN serums, for texture, pores, and fine lines.

Most formulas also lean on niacinamide and adenosine as supporting players, alongside soothing ingredients like centella asiatica or panthenol to keep the stronger actives comfortable on skin.

Which Medicube Serum Is Right for You?

How to Use Medicube Serums in Your Routine

    1. Cleanse and tone. Serums generally follow straight after toning.
    2. Most serums are pressed or patted into the skin rather than rubbed in, which helps with absorption.
    3. Layer thoughtfully. If you’re using more than one serum, apply the thinnest, most watery texture first and heavier or oil based formulas last.
    4. Follow up. Seal everything in with a moisturiser, and use sunscreen in the morning if your serum contains vitamin C, retinol, or exfoliating acids.

    A few of the stronger serums, particularly the exfoliating and retinol formulas, are best kept to an evening routine rather than daily morning use. Check each product’s specific guidance before combining it with other actives.

Frequently Asked Questions

Yes, Medicube serums are well regarded for their formulations and high concentration active ingredients. They consistently deliver visible results at a more accessible price point than many premium skincare brands.

It depends on your skin concern. The PDRN Pink Peptide Serum is best for hydration and repair, the Deep Vita C for brightening,  and the Azelaic Acid Serum for acne and redness.

Medicube serums target specific skin concerns with high concentration actives including brightening, pore refinement, hydration, firming and acne control. Most users see visible improvement within two to four weeks of consistent use.